Human biomarker and genetic analysis
Statens Serum Institut (SSI), department for Congenital Disorders is responsible for the screening of all newborns in Denmark based on analysis of dried blood spot (DBS) samples. We have developed a range of high-sensitive high-capacity multianalyte assays / omics-techniques for analysis of samples for research purposes, see description of the laboratories below.
The Immunoassay lab uses different kinds of technologies for analysis of mainly proteins. The lab is specialized in multiplexing technologies and analysis of small volumes, especially from extractions from DBS samples. We are using assay automatization and have a high capacity. We have several developed in-house assays, and develop almost any kind of customized assay, or we can use commercial kits in our settings as an analytical service. For some assays, we can also offer in-house made antibodies. We have several years of experience in national and international collaboration and analytical services.
We can analyze almost all kinds of sample matrixes, dried blood spot samples, plasma, serum, amniotic fluid, saliva, urin etc.
The most widely used technology is Meso-Scale (multiplex technology) and ELISA.
The Neonatal Genetics lab offers a modern facility using high degrees of automation as well as stringent and traceable workflows. The lab has specialized in whole genome characterizations of neonatal DBS samples using microarray and sequencing technologies, but are also experienced in multiple other sources of material and technologies. The lab is capable of analyzing tens of thousands of samples annually and have contributed to multiple national and international collaborations within the field of genetics.
Genome-Wide analysisWhole genome Genotyping
Whole genome Methylation
Whole Transcriptome analysis
Whole Exome Sequencing
Whole Genome Sequencing
Targeted technologiesTargeted resequencing (all the way down to single exons)
Single Variant determination using qPCR
Multiple variant determination using Mass Array