Antimicrobial evaluation

Statens Serum Institut (SSI) has state of the art laboratories and animal facilities. We offer design, planning and execution of in vitro and in vivo studies.

SSI has developed experimental infection models for the purpose of evaluating antimicrobial drugs. These models are ideal for efficacy screening of new compounds in the discovery phase, proof of concept, as well as for pharmacokinetic and pharmacodynamic studies. Advanced mathematical PK/PD modeling is also used as an integrated part of such studies.

In vitro evaluation of antimicrobials

  • Determination of minimum inhibitory concentrations (MIC)
  • Time kill activity
  • High throughput screening of growth inhibition
  • Serum protein binding by ultrafiltration

In vitro infection models

  • in vitro urinary tract infection model 
  • in vitro kinetic model
  • Medical device related infection

In vivo efficacy studies in murine infection models

  • Peritonitis/Sepsis
  • Thigh infection
  • Urinary tract infection
  • Skin infection 
  • Pneumonia
  • Fungal sepsis
  • Foreign body infection

In vivo pharmacology

  • Bio availability
  • Tissue concentrations
  • Dosage regimens
  • Mathematical PK/PD modeling
  • Dosing recommendations

Antimicrobial susceptibility testing

  • Evaluation of methods for antimicrobial susceptibility testing
  • Evaluation of new in vitro diagnostics
  • Typing of microbial strains
  • Characterization of mechanisms of antimicrobial resistance

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More information

Carina Vingsbo Lundberg

Contact

Carina Vingsbo Lundberg
T. +45 32688209 @. cvl@ssi.dk View profile