Antimicrobial evaluation

Statens Serum Institut (SSI) has state of the art laboratories and animal facilities. We offer design, planning and execution of in vitro and in vivo studies.

SSI has developed experimental infection models for the purpose of evaluating antimicrobial drugs. These models are ideal for efficacy screening of new compounds in the discovery phase, proof of concept, as well as for pharmacokinetic and pharmacodynamic studies. Advanced mathematical PK/PD modelling is also used as an integrated part of such studies.

In vitro evaluation of antimicrobials

  • Determination of minimum inhibitory concentrations (MIC)
  • Time kill activity

In vivo efficacy studies in murine infection models

  • Peritonitis/Sepsis
  • Thigh infection
  • Urinary tract infection
  • Skin infection
  • Pneumonia
  • Fungal sepsis

In vivo pharmacology

  • Pharmacokinetics (PK)
  • Pharmacodynamics (PD)
  • Mathematical PK/PD modelling
  • Dosing recommendations

Antimicrobial susceptibility testing

  • Evaluation of methods for antimicrobial susceptibility testing
  • Evaluation of new in vitro diagnostics
  • Typing of microbial strains
  • Characterization of mechanisms of antimicrobial resistance



Carina Vingsbo Lundberg


Carina Vingsbo Lundberg , Bakterier, parasitter og svampe / Antibiotikaresistens og kontraktforskn.
T. +45 32688209 @. View profile