Assay design and development

At Statens Serum Institut (SSI) we have a long-term experience in quantitative detection of virus and virus-specific antibodies using the haemagglutination (HA) assay and the haemagglutination inhibition (HAI) assay.

Haemagglutination and haemagglutination inhibition assay

The HA assay is a state-of-the-art method for detection and quantitation of specific viruses. Likewise, the HAI assay is a well-described method for detection of antibodies raised against a specific virus or vaccine. At SSI, we have in-depth experience from research as well as contract work in performing both of these assays. We offer detection of virus and virus-specific antibodies in clinical samples, cell cultures and bulk materials using the HA and HAI assay, respectively. Both assays can be performed as quantitative and will be carried out in BL2/BL3 environments. 

As the National WHO Reference Laboratory for several viruses, including influenza virus, we possess not only high international expertise within the field but also a unique collection of viruses and antisera, which can be included in the analysis as references/controls.

Both assays require the addition of red blood cells, and we possess a steady supply of blood from a broad selection of relevant animals such as guinea pig, chicken etc.

Studies can be carried out as individual projects or according to a contract work agreement. If needed, we have the expertise to develop or optimize assays to full-fill the requirements from our contract partner.

  • Detection and quantitation of virus

  • Detection and quantitation of virus-specific antibodies

  • Typing and subtyping of influenza virus

  • Typing and  subtyping of influenza-specific antibodies

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Antimicrobial evaluation

Antimicrobial evaluation

Statens Serum Institut (SSI) has state of the art laboratories and animal facilities. We offer design, planning and execution of in vitro and in vivo studies.
Detection of viruses

Detection of viruses

The unbiased DNA microarray testing has emerged as a promising new technology for broad-spectrum virus detection (metagenomic diagnostic), making it possible to test for the presence of thousands of viruses simultaneously without having a clear predetermination of what to look for. This is convenient e.g. in diagnostic for disease syndromes, in hematological patients, in travellers with exotic virus, and difficult to diagnose patients. We have developed a microarray platform, Pan-Virus Array.
Development of monoclonal and polyclonal antibodies

Development of monoclonal and polyclonal antibodies

Statens Serum Instititut (SSI) has about 35 years of experience in developing and producing monoclonal antibodies and more than 100 years of experience in production of polyclonal antibodies. SSI uses different species of animals for this purpose.
Experimental infection models

Experimental infection models

SSI has state of the art laboratories and animal facilities. We offer design, planning and execution of in vivo experimental infection studies. These models can be used for studying host pathogen interactions, host responses, bacterial virulence and antibiotic treatment.
Claus Nielsen

Contact

Claus Nielsen, Director, MSc, PhD, Virus & Mikrobiologisk Specialdiagnostik
T. +45 32683280 @. cn@ssi.dk View profile