Katrine Grimstrup Joensen

Research area

Research within the development of Next-generation sequencing (NGS)-based surveillance and outbreak detection of food borne pathogenic bacteria.  Primarily by analysis of whole-genome sequence (WGS) data of Campylobacter, but also including WGS-based projects on Shiga toxin-producing E. coli (STEC), and C. difficile.

PubMed link

Katrine Grimstrup Joensen

Responsibilities

• Development and implementation of whole-genome sequencing (WGS) -based typing methods for use in national surveillance of foodborne pathogenic bacteria
  • primarily for Campylobacter, STEC, (C. difficile).

• Development, implementation and maintenance of databases for extracting genetic markers, e.g. virulence genes, serotype-specific genes and resistance markers, for surveillance. 

• Surveillance and outbreak detection 
  
  • within STEC, Listeria and Campylobacter.

Publications

• Joensen KG, Schjørring S, Gantzhorn MR, Vester CT, Nielsen HL, Engberg JH, Holt HM, Ethelberg S, Müller L, Sandø G, Nielsen EM. Whole genome sequencing data used for surveillance of Campylobacter infections: detection of a large continuous outbreak, Denmark, 2019. Euro Surveill. 2021 Jun;26(22):2001396. doi: 10.2807/1560-7917.ES.2021.26.22.2001396. PMID: 34085631; PMCID: PMC8176674.
  
  
• Joensen KG, Kiil K, Gantzhorn MR, Nauerby B, Engberg J, Holt HM, Nielsen HL, Petersen AM, Kuhn KG, Sandø G, Ethelberg S, Nielsen EM. Whole-Genome Sequencing to Detect Numerous Campylobacter jejuni Outbreaks and Match Patient Isolates to Sources, Denmark, 2015-2017. Emerg Infect Dis. 2020 Mar;26(3):523-532. doi: 10.3201/eid2603.190947. PMID: 32091364; PMCID: PMC7045838.
  
  
• Joensen KG, Engsbro ALØ, Lukjancenko O, Kaas RS, Lund O, Westh H, AarestrupFM. Evaluating next-generation sequencing for direct clinical diagnostics in diarrhoeal disease. Eur J Clin Microbiol Infect Dis. 2017 Jul;36(7):1325-1338.doi: 10.1007/s10096-017-2947-2.
  
  
• Joensen KG, Tetzschner AM, Iguchi A, Aarestrup FM, Scheutz F. Rapid and Easy In Silico Serotyping of Escherichia coli Isolates by Use of Whole-Genome Sequencing Data. J Clin Microbiol. 2015 Aug;53(8):2410-26. doi:10.1128/JCM.00008-15. Epub 2015 May 13.
  
  
• Joensen KG, Scheutz F, Lund O, Hasman H, Kaas RS, Nielsen EM, Aarestrup FM. Real-time whole-genome sequencing for routine typing, surveillance, and outbreak detection of verotoxigenic Escherichia coli. J Clin Microbiol. 2014May;52(5):1501-10. doi: 10.1128/JCM.03617-13. Epub 2014 Feb 26.