Malaria Vaccine Research

Malaria is a devastating vector-borne disease caused by the Plasmodium parasite, resulting in almost 0.5 million casualties per year. At Statens Serum Institut (SSI), we are developing malaria vaccines to children and adults in malaria endemic areas.

The Plasmodium parasite has a complex life-cycle that includes asexual replication in human red blood cells, causing symptomatic malaria, and sexual stages which are essential for the transmission to the mosquito vector. A vaccine targeting the asexual blood-stages, which seeks to limit but not prevent parasitaemia holds to potential to protect against clinical disease. However, a vaccine targeting the sexual stages of the parasite and thus blocking transmission will be instrumental for the eradication of malaria.