Research in Section for Biomarkers, Immunology and Antibodies
The research within Section for Biomarkers, Immunology and Antibodies focuses on protein biomarkers, where we try to discover biomarkers to understand especially psychiatric illnesses and premature birth, as well as biomarkers to predict later complications.
Focus areas & research aims
We search for biomarkers in the newborn that can increase our knowledge and understanding of the development and/or predict the later diagnosis of psychiatric illnesses, particularly within autism, ADHD, schizophrenia and affective disorders. We develop antibodies for diagnostics and research use.
Correlations and Diagnoses for Biomarkers in Newborns. This project includes all preterm births within two full years with matching controls born at term. We investigate biomarkers that can explain the preterm birth and its complications.
Multiplex protein analyses
We design and develop analyses for research projects of our own and for others – both as research collaborations and as an assay service. We are specialized in analyzing inflammatory markers in protein extracts from full blood dried out on filter paper, where there is very limited material available, but we can also perform analyses on a variety of sample types, including plasma and serum. In addition, we are able to, and have experience with, analyzing nearly all sample types stored in the Danish National Biobank.
We have a high throughput setup and we have done analyses in project including up to 80,000 samples. SSI Antibodies is part of our section, which we take great benefit from. Several of our assays thus include high quality antibodies from SSI Antibodies. In addition, we have the possibility to design and produce novel antibodies, if our research projects require this.
- Delivery Modality Affect Neonatal Levels of Inflammation, Stress, and Growth Factors.
- Effects of blood sample handling procedures on measurable inflammatory markers in plasma, serum and dried blood spot samples.
- Multiplex assays of inflammatory markers, a description of methods and discussion of precautions - Our experience through the last ten years.
- Reduced neonatal brain-derived neurotrophic factor is associated with autism spectrum disorders.
- Simultaneous measurement of 25 inflammatory markers and neurotrophins in neonatal dried blood spots by immunoassay with xMAP technology.
Examples of research projects
- CODIBINE - Correlations and Diagnoses for Biomarkers in Newborns
- iPSYCH - The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- SHARE - Survey of Health, Ageing and Retirement in Europe
- Theirworld Edinburgh Birth Cohort