One Health-research

Statens Serum Institute (SSI) participates in a number of Danish and international One Health research projects and networks. Read more about some of our One Health research projects below.

ADONIS - Assessing determinants of the non-decreasing incidence of Salmonella

Salmonellosis remains the second most common zoonosis in humans in the EU despite a long-term decreasing trend in human cases. In recent years, this decreasing trend has levelled off. In laying hens, the prevalence of positive flocks for especially S. Enteritidis, has increased after a long period of documented reduction. Several hypotheses have been used to explain these trends. The ADONIS project will identify determinants underlying the stagnation/reversal of the decreasing trend in Salmonella Enteritidis incidence. We will apply a cross-sectorial approach where we will investigate both primary production, epidemiology/exposure, and the pathogen itself.

Partners: AGES (Austria), ANSES (France), APHA (UK), INIAV (Portugal) INSA (Portugal), IP (France), ISS (Italy), PHE (UK), PIWET (Poland), RIVM (Holland), Sciensano (Belgium), SSI (Denmark), VISAVET-UCM (Spain), and WBVR (Holland).

More information.

Contact:
Senior researcher Eva Litrup

Campylobacter transmission in broiler chickens investigated by genome sequencing

The goal is to reduce the number of chicken flocks infected with Campylobacter and thereby reduce the number of human Campylobacter infections caused by consumption of Danish broiler chickens. The objective is to improve the control measures of Campylobacter in the broiler production by providing new data and knowledge on the level of transmission between flocks and farms. The new knowledge will be achieved by whole genome sequencing of bacterial isolates and will make it possible to improve the follow-up and prevention of Campylobacter at the farms.

Partners: The largest poultry abattoirs in Denmark. The project is funded by the Poultry Production Levy Fund.

Contact:
Head of unit Eva Møller Nielsen

CARE: Cross-sectoral framework for quality Assurance Resources for countries in the European Union

The project will develop new proficiency testing schemes that can be used cross-sectors and thereby be used to evaluate the capacity to manage bacterial foodborne disease problems from a One Health perspective. The project will furthermore investigate the availability and sustainability of reference material, provided by reference laboratories, online repositories, and national collections and access the quality and availability of the demographic data, e.g. data on food and feed consumption.

Partners: Multiple partners within the OHEJP.

More information.

Contact:
Head of unit Mia Torpdahl
Academic officer Jeppe Boel

FARMED: Fast Antimicrobial Resistance and Mobile-Element Detection using metagenomics for animal and human on-site tests

The FARMED project aims to develop on-site diagnostic tools for pathogen and AMR detection. Environment and clinical samples will be target for DNA extraction and metagenomic sequencing by ONT MinION in order to attribute AMR with specific species and plasmids, within the bacterial community.

Partners: Complutense University of Madrid (VISAVET-UCM), Madrid, Istituto Superiore di Sanità (ISS), Italy, Animal Plant Health Protection Agency (APHA), United Kingdom, SciensanoRue, Belgium, Wageningen Bioveterinary Research (WBVR), The Netherlands, The German Federal Institute for Risk Assessment (BfR), Germany, Statens Serum Institut (SSI), Denmark, DTU National Food Institute (DTU), Denmark.

More information.

Contact:
Senior researcher Søren Persson
Researcher Søren Overballe-Petersen 

FED-AMR: The role of free extracellular DNA in dissemination of antimicrobial resistance over ecosystem boundaries along the food/feed chain 

The Hydrology Open Air Laboratory (HOAL) in Austria will be used to investigate horizontal antimicrobial resistance gene (ARG) transfer on free extracellular DNA (exDNA) over ecosystem boundaries, where Acinetobacter sp. (transformation) and C. difficile (conjugation) will serve as model organisms. In parallel, C. difficile will be collected from different human and non-human environments and bacterial isolates will be analyzed for AMR, typing and phylogenetic overlap between the different origins.

Partners: National Health Institute (INSA), Portugal, Institut Pasteur (IP), France, National University of Ireland Galway (NUIG), Ireland, Austrian Agency for Health and Food Safety (AGES), Austria, National Institute of Public Health (SZU), National Institute of Public Health (SZU) Czech Republic, The German Federal Institute for Risk Assessment (BfR), Germany, Statens Serum Institut (SSI), Denmark, Norwegian Veterinary Institute (NVI), Norway.

More information.

Contact:
Senior researcher Søren Persson 

FluZooMark influenza One Health center

FluZooMark is an influenza One Health Center focused on determining factors that influences the capability of influenza viruses to cross species barriers and be the cause of zoonotic transmission and possibly future pandemics. The center involves leading researchers with unique knowledge about virology and immunology in the field of influenza. The center is an international collaboration funded by the Novo Nordisk foundation.

Partners: University of Copenhagen, Denmark, Statens Serum Institut, Denmark, Technical University of Denmark, and St. Judes Children´s Research Hospital, Memphis, USA.

More information.

Contact:
Head of unit Ramona Trebbien 

MATRIX 

MATRIX aims to advance the implementation of One Health Surveillance (OHS) in practice, by building on existing resources, adding value to them and creating synergies among the sectors. In particular, identifying and describing existing cross-sectorial OHS programmes or potential programmes, extending the efforts of existing integrative OHEJP projects, which focus on separate or only two sectors.

Partners: Multiple partners within the OHEJP.

More information.

Contact:
Academic officer Diana Connor 

Metagenomic Array Detection of emerging Virus in EU (MAD-Vir)

The MAD-Vir Project aim is to validate a metagenomics PanVirus microarray technology for fast detection of viral FBZ agents and emerging threats in humans and/or domestic and wildlife animals.

Partners: INIA-CISA (Spain), ANSES (France), UoS (UK), APHA (UK), IZSAM (Italy), IZSLER (Italy), PIWET (Poland), VRI (Czech Republic), NPHC (Hungary) and SSI (Denmark).

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Contact:
Chief Physician Anders Fomsgaard 

NOVA: Novel approaches for design and evaluation of cost-effective surveillance across the food chain

The NOVA project strives to develop new surveillance tools and methods and to harmonise and optimise the use of existing surveillance system data. NOVA, is expected, through its collaborative structure, to help advance the use of modern surveillance principles across Europe. Moreover, the outcomes developed will have practical and cost-saving impacts on how surveillance of existing and emerging zoonotic agents is being conducted within the EU.

Partners: OHEJP.

More information

Contact:
Head of unit, Professor Steen Ethelberg 

OH-HARMONY-CAP: One Health Harmonization of Protocols for the Detection of Foodborne Pathogens and AMR Determinants

OH-Harmony-Cap aims to describe the current capabilities, capacities and interoperability to detect priority bacteria and parasites across OH sectors by providing an in depth OHLabCap tool by surveying the National Reference Laboratories (NRL) and the primary diagnostic laboratories. This description, of current and best practices, and the development of harmonised protocols will identify and possibly close gaps and suggest future studies on how best to detect and characterise food borne pathogens across the OH sectors.

Partners: ANSES-FR; BfR-DE; APHA-UK; Teagasc-I.E.; RIVM-NL; NIPH-NO; NVI-NO; INIAV-PT; INSA-PT; SLV-SE; FoHM-SE; SVA-SE; PIWet-PL; ISS-IT; SSI-DK.

More information.

Contact:
Senior scientist Nadia Boisen
Head of unit Flemming Scheutz 

ORION: One Health Surveillance Initiative on Harmonization of Data Collection and Interpretation

ORION aims to establish and strengthen inter-institutional collaboration and transdisciplinary knowledge transfer in the area of surveillance data integration and interpretation, along the One Health (OH) objective of improving health and well-being. The project involves 13 veterinary and/or public health institutes from 7 European countries. These institutes are committed to adopt best practice One Health Surveillance solutions (guidelines, methods, tools and knowledge).

Partners: Multiple partners within the OHEJP.

More information.

Contact:
Head of unit Eva Møller Nielsen 

Point-of-incidence toolbox for emerging virus threats (TELE-Vir)

The TELE-Vir project key aim is to develop a very fast point-of-incidence (poi) toolbox for identification and characterization of emerging virus threats for humans and/or domestic and wildlife animals using MinION third-generation sequencing.

Partnere: INIA-CISA (Spain), ANSES (France), UoS (UK), IZSAM (Italy), IZSLER (Italy), PIWET (Poland), VRI (Czech Republic), INSA (Portugal), SVA (Sweden), NVI (Norway), Sciensano (Belgium) and SSI (Denmark).

More information.

Contact:
Chief Physician Anders Fomsgaard 

TOXOSOURCES – Toxoplasma gondii sources quantified 

TOXOSOURCES is a One Health Consortium that focuses on Toxoplasma gondii. TOXOSOURCES investigates the sources of human infection, and the contribution of the different sources, using several approaches.

Partners: Several OHEJP partners.

More information.

Contact:
Academic officer Pikka Jokelainen 

Zoonotic transmission of antimicrobial resistance (FULL FORCE)

The purpose of the FULL FORCE project is to combine different sequencing technologies to study possible clonal and horizontal dissemination of antimicrobial resistance from bacteria in animals and food products to humans across Europe. The project will focus on plasmid-borne resistance towards cephalosporins (in relation to ESBL and pAmpC producing organisms), carbapenems (in relation to carbapenemase producing organisms) and colistin. The project is partly funded by the One Health European Joint Program (EJP) under the Horizon 2020 programme.

Partners: Multiple partners within OHEJP.

More information.

Contact:
Senior researcher Henrik Hasman