One Health-research

Salmonellosis remains the second most common zoonosis in humans in the EU despite a long-term decreasing trend in human cases. In recent years, this decreasing trend has levelled off. In laying hens, the prevalence of positive flocks for especially S. Enteritidis, has increased after a long period of documented reduction. Several hypotheses have been used to explain these trends. The ADONIS project will identify determinants underlying the stagnation/reversal of the decreasing trend in Salmonella Enteritidis incidence. We will apply a cross-sectorial approach where we will investigate both primary production, epidemiology/exposure, and the pathogen itself.

Partners: AGES (Austria), ANSES (France), APHA (UK), INIAV (Portugal) INSA (Portugal), IP (France), ISS (Italy), PHE (UK), PIWET (Poland), RIVM (Holland), Sciensano (Belgium), SSI (Denmark), VISAVET-UCM (Spain), and WBVR (Holland).

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Contact:
Senior researcher Eva Litrup

BeONE will develop an integrated surveillance dashboard in which molecular and epidemiological data for foodborne pathogens can be interactively analysed, visualised and interpreted by the relevant experts across disciplines in the public health/animal health/food safety sectors. The project will develop a tailored surveillance system, facilitating consistent definition of outbreaks across domains and countries by the use of new algorithms based on integrated genomic and epidemiological data, as well as facilitating communication and flexible data sharing.

Partners: Multiple partners within the OHEJP.

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Contact:
Kristoffer Kiil 

The goal is to reduce the number of chicken flocks infected with Campylobacter and thereby reduce the number of human Campylobacter infections caused by consumption of Danish broiler chickens. The objective is to improve the control measures of Campylobacter in the broiler production by providing new data and knowledge on the level of transmission between flocks and farms. The new knowledge will be achieved by whole genome sequencing of bacterial isolates and will make it possible to improve the follow-up and prevention of Campylobacter at the farms.

Partners: The largest poultry abattoirs in Denmark. The project is funded by the Poultry Production Levy Fund.

Contact:
Head of unit Eva Møller Nielsen

The project will develop new proficiency testing schemes that can be used cross-sectors and thereby be used to evaluate the capacity to manage bacterial foodborne disease problems from a One Health perspective. The project will furthermore investigate the availability and sustainability of reference material, provided by reference laboratories, online repositories, and national collections and access the quality and availability of the demographic data, e.g. data on food and feed consumption.

Partners: Multiple partners within the OHEJP.

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Contact:
Head of unit Mia Torpdahl
Academic officer Jeppe Boel

The project brings together experts from different disciplines and sectors to address the challenges of source attribution in an interdisciplinary manner. As there is no gold standard for source attribution, we will take a comprehensive approach applying several different methodologies and models in a comparative fashion. The work will focus on evaluating and advancing existing methods as well as explore and develop novel approaches for source attribution. The source attribution estimates will focus on three pathogens (Salmonella, Campylobacter, and STEC) and AMR.

Partners: 19 partners from 13 countries within the OHEJP.

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Contact:
Head of section Eva Møller Nielsen

The FARMED project aims to develop on-site diagnostic tools for pathogen and AMR detection. Environment and clinical samples will be target for DNA extraction and metagenomic sequencing by ONT MinION in order to attribute AMR with specific species and plasmids, within the bacterial community.

Partners: Complutense University of Madrid (VISAVET-UCM), Madrid, Istituto Superiore di Sanità (ISS), Italy, Animal Plant Health Protection Agency (APHA), United Kingdom, SciensanoRue, Belgium, Wageningen Bioveterinary Research (WBVR), The Netherlands, The German Federal Institute for Risk Assessment (BfR), Germany, Statens Serum Institut (SSI), Denmark, DTU National Food Institute (DTU), Denmark.

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Contact:
Senior researcher Søren Persson
Researcher Søren Overballe-Petersen 

The Hydrology Open Air Laboratory (HOAL) in Austria will be used to investigate horizontal antimicrobial resistance gene (ARG) transfer on free extracellular DNA (exDNA) over ecosystem boundaries, where Acinetobacter sp. (transformation) and C. difficile (conjugation) will serve as model organisms. In parallel, C. difficile will be collected from different human and non-human environments and bacterial isolates will be analyzed for AMR, typing and phylogenetic overlap between the different origins.

Partners: National Health Institute (INSA), Portugal, Institut Pasteur (IP), France, National University of Ireland Galway (NUIG), Ireland, Austrian Agency for Health and Food Safety (AGES), Austria, National Institute of Public Health (SZU), National Institute of Public Health (SZU) Czech Republic, The German Federal Institute for Risk Assessment (BfR), Germany, Statens Serum Institut (SSI), Denmark, Norwegian Veterinary Institute (NVI), Norway.

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Contact:
Senior researcher Søren Persson 

FluZooMark is an influenza One Health Center focused on determining factors that influences the capability of influenza viruses to cross species barriers and be the cause of zoonotic transmission and possibly future pandemics. The center involves leading researchers with unique knowledge about virology and immunology in the field of influenza. The center is an international collaboration funded by the Novo Nordisk foundation.

Partners: University of Copenhagen, Denmark, Statens Serum Institut, Denmark, Technical University of Denmark, and St. Judes Children´s Research Hospital, Memphis, USA.

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Contact:
Head of unit Ramona Trebbien 

The FULL_FORCE consortium will broadly introduce single molecule real-time (SMRT) sequencing in EU veterinary and public health institutes. Building on JPIAMR’s SOLIDNESS results, we will harmonize, build and test each institute’s SMRT sequencing capacity with focus on mobile genetic elements (MGEs) such as plasmids. We will apply this knowledge on six study cases, which will greatly profit from MGE sequencing, incl. samples isolated in the context of national surveillance programmes, EFFORT and ARDIG projects.

Partners: Anses (France), Sciensano (Belgium), BfR (Germany), DTU (Denmark), SSI (Denmark), INRAE (France), APHA (England), ISS (Italy), RIVM (The Netherlands), WbvR (The Netherlands), NVI (Norway), PIWET (Poland), INIAV (Portugal), INSA (Spain), FoHM (Sweden), SVA (Sweden), UU (The Netherlands), IZSLT (Italy).

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Contact:
Senior Scientist Henrik Hasman
Researcher Søren Overballe-Petersen  

MATRIX aims to advance the implementation of One Health Surveillance (OHS) in practice, by building on existing resources, adding value to them and creating synergies among the sectors. In particular, identifying and describing existing cross-sectorial OHS programmes or potential programmes, extending the efforts of existing integrative OHEJP projects, which focus on separate or only two sectors.

Partners: Multiple partners within the OHEJP.

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Contact:
Academic officer Diana Connor 

MEmE is a One Health Consortium with focus on parasites Echinococcus multilocularis and Echinococcus granulosus s.l.

Partners: Several OHEJP partners.

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Contact:
Academic officer Pikka Jokelainen 

The MAD-Vir Project aim is to validate a metagenomics PanVirus microarray technology for fast detection of viral FBZ agents and emerging threats in humans and/or domestic and wildlife animals.

Partners: INIA-CISA (Spain), ANSES (France), UoS (UK), APHA (UK), IZSAM (Italy), IZSLER (Italy), PIWET (Poland), VRI (Czech Republic), NPHC (Hungary) and SSI (Denmark).

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Contact:
Chief Physician Anders Fomsgaard 

The NOVA project strives to develop new surveillance tools and methods and to harmonise and optimise the use of existing surveillance system data. NOVA, is expected, through its collaborative structure, to help advance the use of modern surveillance principles across Europe. Moreover, the outcomes developed will have practical and cost-saving impacts on how surveillance of existing and emerging zoonotic agents is being conducted within the EU.

Partners: OHEJP.

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Contact:
Head of unit, Professor Steen Ethelberg 

OH-Harmony-Cap aims to describe the current capabilities, capacities and interoperability to detect priority bacteria and parasites across OH sectors by providing an in depth OHLabCap tool by surveying the National Reference Laboratories (NRL) and the primary diagnostic laboratories. This description, of current and best practices, and the development of harmonised protocols will identify and possibly close gaps and suggest future studies on how best to detect and characterise food borne pathogens across the OH sectors.

Partners: ANSES-FR; BfR-DE; APHA-UK; Teagasc-I.E.; RIVM-NL; NIPH-NO; NVI-NO; INIAV-PT; INSA-PT; SLV-SE; FoHM-SE; SVA-SE; PIWet-PL; ISS-IT; SSI-DK.

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Contact:
Senior scientist Nadia Boisen
Head of unit Flemming Scheutz 

ORION aims to establish and strengthen inter-institutional collaboration and transdisciplinary knowledge transfer in the area of surveillance data integration and interpretation, along the One Health (OH) objective of improving health and well-being. The project involves 13 veterinary and/or public health institutes from 7 European countries. These institutes are committed to adopt best practice One Health Surveillance solutions (guidelines, methods, tools and knowledge).

Partners: Multiple partners within the OHEJP.

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Contact:
Head of unit Eva Møller Nielsen 

PARADISE is a One Health Consortium with focus on improved detection and characterization of parasites Cryptosporidium and Giardia.

Partners: Several OHEJP partners.

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Contact:
Academic officer Pikka Jokelainen 

The TELE-Vir project key aim is to develop a very fast point-of-incidence (poi) toolbox for identification and characterization of emerging virus threats for humans and/or domestic and wildlife animals using MinION third-generation sequencing.

Partnere: INIA-CISA (Spain), ANSES (France), UoS (UK), IZSAM (Italy), IZSLER (Italy), PIWET (Poland), VRI (Czech Republic), INSA (Portugal), SVA (Sweden), NVI (Norway), Sciensano (Belgium) and SSI (Denmark).

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Contact:
Chief Physician Anders Fomsgaard 

The goal is to improve the control of Campylobacter in broiler chickens by generating new knowledge on the dynamics of transmission of Campylobacter in chicken flocks and farms, including studies on the transmission in free-range chickens. In Campylobacter positive farms, the Campylobacter isolates will be whole-genome sequenced and analysis of the likely transmission routes will be carried out.

Partners: The largest poultry abattoirs in Denmark. The project is funded by the Poultry Production Levy Fund, 2021.

Contact:
Head of Unit, Eva Møller Nielsen 

TOXOSOURCES is a One Health Consortium that focuses on Toxoplasma gondii. TOXOSOURCES investigates the sources of human infection, and the contribution of the different sources, using several approaches.

Partners: Several OHEJP partners.

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Contact:
Academic officer Pikka Jokelainen