Mads Melbye

Mads Melbye


Mads Melbye, President, CEO, Direktionen / Epidemiologisk Forskning
T. +45 32683163 @.


Research interests include infectious disease epidemiology, effects of vaccines, genetic disposition to disease, perinatal epidemiology and cancer epidemiology.
Mads Melbye has great experience with research based on the linkage of information from Danish registers and biobanks.


Mads Melbye has written more than 600 scientific articles and has an H-index of 90 in Web of Science and 112 in Google Scholar.

Complete list of publications

1988 DMSc
1984 Medical Diploma (MD)

2016- President & CEO, Statens Serum Institut (SSI)
2014- Professor in Medical Epidemiology, University of Copenhagen (10%) 
2013- Visiting Professor, Stanford University School of Medicine 
1992- Head, Dept of Epidemiology Research, SSI 
2015-16 Director, Division of Epidemiology & Disease Surveillance, SSI 
2012-15 Director, Division of National Health Surveillance and Research, SSI 
2004-12 Director, Division of Epidemiology, SSI
1998-2008 Foreign Adjunct Professor, Karolinska Insitutet, Stockholm 
1998-2002 NorFA professor 
1992-97 Professor (personal chair given by the Minister of Education, Bertel Haarder, 'Super 
State Epidemiologist, Dept of Epidemiology, SSI
1988-91 Senior Investigator, Institute of Cancer Epidemiology, The Danish Cancer Registry
1986-88 Intern and resident, Environmental Epidemiology Branch, National Cancer Institute,
NIH, Bethesda, Maryland, USA
Visiting Scientist, Environmental Epidemiology Branch, National Cancer Institute,
NIH, Bethesda, Maryland, USA
1984-85 Research Fellow, The Institute of Cancer Research, Aarhus

Committees (selected)
2019-  Member of the Scientific Committee, Oslo University Hospital, Oslo, Norway
2018- Member, Biobank Sweden's Scientific Advistory Board
2017- Chairman, Governing Council, WHO's International Agency for Research on Cancer
(IARC), Lyon, France
Member of the International Scientific Advisory Board, UK Biobank
2011- Member of Lægevidenskabens Fremme, AP Møller og hustru Chastine Mc-Kinney
2005- Chairman of the Scientific Committee, the Danish Heatlh Insurance Fond
Chairman, Board of Scientific Councillors, WHO's International Agency for Research
on Cancer (IARC), Lyon, France
2007-17 Member of the Novo Nordisk Prize Committee
2007-10 Chairman, Board of the Nordic Medical Research Councils (NOS-M)
2006-10 Vice-chairman, Danish Medical Research Council
Member of the Danish Medical Research Council
2002-12 Chairman, Ministry of Science, Technology and Innovation's Coordinating Group
regarding Registry Research 
2000-01 Chairman, Ministry of Research and Technology's Working Group on Registry 

Prizes and Honours
2014 The Erhoff Prize
2005 The Novo Nordisk Prize
1998 The Thorvald Madsen Prize
1993 Ipsen Lecture
1992 The Anders Jahre Prize, Oslo, Norway
1989 AIDS Fonden Prize
1985 Hjortenberg Foundation Prize
1983 Gold Medal of the University of Aarhus, Denmark, for a thesis on microbiology and

Selected publications
Hviid A, Hansen JV, Frisch M, Melbye M. Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. Ann Intern Med. 2019 [Epub ahead of print]: doi:10.7326/M18-2101 (Has already reached the 8th highest attention score (n=8108) in altmetric out of 12,7714,558 published articles worldwide) 
Husby A, Wohlfahrt J, Øyen N, Melbye M. Pregnancy duration and breast cancer risk. Nat Commun 2018;9:4255. doi: 1038/s41467-018-06748-3 
Ngo TTM, Moufarrej MN, Rasmussen M-LH, Camunas-Soler J, Pan W, Okamoto J, Neff NF, Liu K, Wong RJ, Downes K, Tibshirani R, Shaw GM, Skotte L, Stevenson DK, Biggio JR, Elovitz MA, Melbye M*, Quake SR*. Noninvasive blood tests for fetal development predict gestational age and preterm delivery. (*shared last author) Science 2018; 360:1133-1136 
Demenais F, Margaritte-Jeannin P, Barnes KC, ........ Melbye M, ........ Yang JH, Moffatt MF, Ober C, Nicolae DL. Multi-ancestry genome-wide association study identifies new asthma risk loci that colocalize with immune cell enhancer marks. Nat Genet 2018; Jan;50(1):42-53. doi: 10.1038/s41588-017-0014-7 
Rasmussen M-LH, Strøm M, Wohlfahrt J, Videbech P, Melbye M. Risk, treatment duration, and recurrence risk of postpartum affective disorder in women with no prior psychiatric history: a population-based cohort study. PLoS Medicine 2017;14:e1002382 
Zhang G, Feenstra, Bacelis J, .... Melbye M, Jacobsson B, Muglia LJ. Genetic associations with gestational duration and spontaneous preterm birth. N Engl J Med 2017; DOI: 10.1056/NEJMoa1612665
Behrens I, Basit S, Lykke JA, Ranthe MF, Wohlfahrt J, Bundgaard H, Melbye M, Boyd HA. Association between hypertensive disorders of pregnancy and later risk of cardiomyopathy. JAMA 2016;315:1026-33 
Charlton BM, Mølgaard-Nielsen D, Svanström H, Wohlfahrt J, Pasternak B and Melbye M. Maternal use of oral contraceptives and risk of birth defects in Denmark: prospective, nationwide cohort study. BMJ 2016;352:doi:hhtp:// 
Mølgaard-Nielsen D, Svanström H, Melbye M, Hviid A, Pasternak B. The association between use of oral fluconazole during pregnancy and risk of spontaneous abortion and stillbirth. JAMA 2016;315:58-67
Feenstra B, Pasternak B, Geller F, Carstensen L, Wang T, Huang F, Eitson JL, Hollegaard MV, Svanström H, Vestergaard M, Hougaard D, Schoggins JW, Jan LY, Melbye M and Hviid A. Common variants associated with general and MMR vaccine-related febrile seizures. Nat Genet 2014;46:1274-1282 
Geller F, Feenstra B, Carstensen L, Pers TH, van Rooij IALM, Körberg IB, Choudhry S, Karjalainen J, Schnack T, Hollegaard MV, Feitz WFJ, Roeleveld N, Hougaard D, Hirschhorn JN, Franke L, Baskin LS, Nordenskjöld A, van der Zanden LFM, Melbye M. Genome-wide association analyses identify variants in developmental genes associated withy hypospadias. Nat Genet 2014;46:957-63 
Lund M, Pasternak B, Davidsen RB, Feenstra B, Krogh C, Wohlfahrt J and Melbye M. Use of macrolides in mother and child and risk of pyloric stenosis: Nationwide Cohort Study. BMJ 2014;348:g1908 
Hviid A, Melbye M, Pasternak B. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N Engl J Med 2013;369:2406-15
Feenstra B, Geller F, Carstensen L, Romitti PA, Körberg IB, Bedell B, Krogh C, Fan R, Svenningson A, Caggana M, Nordenskjöld A, Mills JL, Murray JC, Melbye M. Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis. JAMA 2013;310:714-21 
Feenstra B, Geller F, Krogh C, Hollegaard MV, Gørtz S, Boyd HA, Murray JC, Hougaard DM, Melbye M. Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis. Nat Genet 2012;44:334-7 
Biggar RJ, Wohlfahrt J, Oudin A, Hjuler T, Melbye M. Digoxin use and the risk of breast cancer in women. J Clin Oncol 2011;29:2165-70
Krogh C, Fischer TK, Skotte L, Biggar RJ, Øyen N, Skytthe A, Gørtz S, Christensen K, Wohlfahrt J, Melbye M. Familial aggregation and heritability of pyloric stenosis. JAMA 2010; 303:2393-2399 
Edgren G, Hjalgrim H, Reilly M, Tran TN, Rostgaard K, Shanwell A, Titlestad K, Adami J, Wikman A, Jersild C, Gridley G, Wideroff L, Nyrén O, Melbye M. Risk of cancer after blood transfusion from donors with subclinical cancer. Lancet 2007; 369:1724-1730 
Ahlgren M, Melbye M, Wohlfahrt J and Sørensen TIA. Growth patterns and risk of breast cancer. N Engl J Med 2004;351:1619-1626 
Madsen KM, Vestergaard M, Schendel D, Wohlfahrt J, Thorsen P, Olsen J, Melbye M. A population-based study of measles, mumps and rubella vaccination and autism. N Engl J Med 2002; 347:1477-1482 
Mortensen PB, Pedersen CB, Westergaard T, Wohlfahrt J, Ewald H, Mors O, Andersen PK, Melbye M. Effect of family history and place and season at birth on the risk of schizophrenia. N Engl J Med 1999; 340:603-608 
Frisch M, Glimelius B, van den Brule AJC, Wohlfahrt J, Meijer CJLM, Walboomers JMM, Adami HO, Melbye M. A sexually transmitted infection as a cause of anal cancer. N Engl J Med 1997; 337:1350-1358
Melbye M, Wohlfahrt J, Olsen JH, Frisch M, Westergaard T, Larsen KH, Andersen PK. Induced abortion and the risk of breast cancer. N Engl J Med 1997; 336:81-85 
Melbye M, Sprøgel P. Aetiological parallel between anal cancer and cervical cancer. Lancet 1991; 338:657-659
Melbye M, Froebel K, Madhok R, Biggar RJ, Sarin P, Stenbjerg S, Lowe C, Forbes CD, Goedert JJ, Gallo RC, Ebbesen P. HTLV-III seropositivity in European haemophiliacs exposed to factor VIII concentrate imported from the USA. Lancet 1984; ii:1444-1446