Helena Strand Clemmensen
As PhD student in the Tuberculosis (TB) Vaccine group at SSI, I am working on characterizing our newest TB vaccine candidate using the mouse model. My research is centered on identifying and understanding protective immunity against Mycobacterium tuberculosis (Mtb) – both during natural Mtb infection and after vaccination. Particularly, I am studying the expression and immunogenicity of Mtb antigens during chronic TB infection, and how this affects the functionality of antigen specific T cells.
- Vaccine mediated T cell immunity and protection
- T cell functionality, lung migration and differentiation
- Recognition of Mtb antigens during late chronic TB infection
- Vaccine design and delivery
- PhD student in the TB Vaccine Research Group at the Department of Infectious Disease Immunology
- Mortensen, R., Clemmensen, H. S., Woodworth, J. S., Therkelsen, M. L., Mustafa, T., Tonby, K., Andersen, P. (2019). Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice. Communications Biology, 2(1), 288.
- Clemmensen, H. S., Knudsen, N. P. H., Rasmussen, E. M., Winkler, J., Rosenkrands, I., Ahmad, A., Aagaard, C. (2017). An attenuated Mycobacterium tuberculosis clinical strain with a defect in ESX-1 secretion induces minimal host immune responses and pathology. Scientific Reports, 7, 46666.