Dennis Christensen

Dennis Christensen

Contact

Dennis Christensen , Afdeling for Infektionsimmunologi / Adjuvans
T. +45 32683804 @. den@ssi.dk

Research areas

Design and characterization of novel vaccine adjuvants for prophylactic as well as therapeutic vaccines. The application and characterization of liposome-based vaccine delivery systems for vaccine antigens and immunostimulators. The investigation on how physical and chemical properties of vaccine delivery systems and route of administration affects the vaccine induced immune responses.

 

Responsibilities

  • Head of Vaccine Adjuvant Research
  • Responsible for strategic alliances and external collaborations

 

Selected publications

  • Christensen D, Hansen L.B, Leboux R, Jiskoot W, Christensen J.P, Andersen P and Dietrich J. A Liposome-Based Adjuvant Containing Two Delivery Systems with the Ability to Induce Mucosal Immunoglobulin A Following a Parenteral Immunization.  ACS Nano. 2019; DOI: 10.1021/acsnano.8b05209.
  • Schmidt S.T, Pedersen G.K, Neustrup M.A, Korsholm K.S, Rades T, Andersen P, Foged C, Christensen D. Induction of Cytotoxic T-Lymphocyte Responses Upon Subcutaneous Administration of a Subunit Vaccine Adjuvanted With an Emulsion Containing the Toll-Like Receptor 3 Ligand Poly(I:C). Frontiers in Immunology. 2018; 9:898.
  • Pedersen G.K, Andersen P, Christensen D. Immunocorrelates of CAF family adjuvants. Seminars in Immunology. 2018; 39: DOI: 10.1016/j.smim.2018.10.003.
  • Christensen D, Christensen J.P, Korsholm K.S, Isling L.K, Erneholm K, Thomsen A.R, Andersen P. Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant. Frontiers in Immunology. 2018; 8:1928.
  • Schmidt S.T, Khadke S, Korsholm K.S, Perrie Y, Rades T, Andersen P, Foged C, Christensen D. The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8+ T-cell responses: The immunological consequences of the biodistribution profile. Journal of Controlled Release. 2016; 239:107-117..

 

Researchgate link

Complete publication list: http://www.researchgate.net/profile/Dennis_Christensen2